Sustainable Development Goal (SDG) targets for rapid reduction of maternal, stillbirth, and newborn mortality will only be reached if known evidence-based interventions can be delivered by country health systems using designs that are effective, scalable, and sustainable. The content and methods for effective and scalable interventions must be simple, focused, and transferable. Sustainability requires minimal reliance on external technical resources. We show examples of how quality improvement (QI) methods have been adapted to include clinical and health system interventions, how focused clinical bundles can lead to rapid adoption of best practices at scale, and how country health systems can be supported to rapidly and independently scale successful maternal, newborn, and child health (MNCH) interventions. This panel will showcase the journey from demonstration of effectiveness to methods for scale and government-led scale-up. With examples from Brazil, Ethiopia, and Bangladesh, practioners from the field and government planners will describe innovative approaches to improving safety of maternal care, the use of clinical and administrative bundles to improve reliability of care, rapid replication designs to improve uptake of best practice clinical care, and what it takes to integrate new implementation designs and QI capability into government-led scale-up of MNCH programming.